CAPHIV : Early detection of HIV-1 using ultra-sensitive, rapid capacitive biosensor

The HIV pandemic is a worldwide public-health problem. At the end of 2008 there were an estimated 850.000 people infected with HIV in western and central Europe and  25.656 new cases were reported by the countries of the EU and EEA in 2008.

The most commonly used and widely accessible diagnostic tests rely on the presence of HIV antibodies. Seroconversion, however, can take up to six months which prevents the early detection of the infection. Moreover, newborns cannot be tested with these methods due to maternal antibodies masking their true HIV status.

CapHIV

The CAPHIV project aims at developing a quick and automatic biosensor that targets the detection of a protein produced in the early stages of the disease and not that of an antibody. The device is expected to diagnose the disease within two weeks of the infection. The applied technology is to reduce measurement time and reduce costs associated with HIV testing.

 The consortium guarantees complementary and synergistic business interests, ensuring a rapid and dynamic route of the technology to the market.

 The research activity of the Hungarian partner, MFKK Hungarian Invention and Research Centre Services Ltd., will be focused on the development of the cartridge design and production and system integration. Lund University Department of Biotechnology will adapt the previously developed the capacitive sensor for the CapHIV project and perform research regarding the characterization and immobilization of antibodies. The SMEs will be responsible for the creation of the technology push, being fully capacitated to manufacture the developed technology.

 The whole budget of the project is 1.282.000€, out of which  936.500€ will be funded by the European Union within the 286798 FP7 project agreement.

Duration of the project: 1st of September, 2011- 31st of August, 2013

Participants:

MFKK Hungarian Invention and Research Centre Ltd.. – Hungary

Capsenze Handelsbolag – Sweden

Phenosystems SA – Switzerland

Lionex Gmbh – Germany

ABBCN S.L. – Spain

Fima Srl. – Italy

Lund University– Sweden